Nitrase Therapeutics (NTx) is a preclinical platform company developing disease modifying therapeutics against a novel class of enzymes to treat age related disorders: oncological, neurological, cardiovascular, fibrotic and inflammatory diseases. This is a unique opportunity to join an innovative biotech start-up committed to advancing cutting-edge science to discover transformative medicines for patients with unmet medical needs.Senior Research Associate (SRA)/Associate Scientist (AS)/Scientist (S) Position, Translational BiomarkersThe Preclinical Development Department at NTx provides Pharmacology, DMPK, Toxicology, and Translational Biomarker support to inform the development of novel therapeutics of various modalities (small molecule, therapeutic antibody, etc.) and in diverse disease areas. Within the Translational team, our biomarker strategies span all stages of research and drug development from target discovery through the clinic. The Translational team aims to provide diagnostic, prognostic, predictive and pharmacodynamic support by developing and executing biomarker assays that are designed to study and elucidate the molecular pathways driving disease and to establish the mechanism of action of our novel therapeutics.We are seeking a talented and highly motivated Senior Research Associate/Associate Scientist/Scientist to join NTx’s Translational Biomarker team within the Preclinical Development Department in Brisbane, CA. The candidate will collaborate with scientists to identify novel markers and implement quantitative biomarker assays in preclinical models and clinical samples.Responsibilities:Collaborate across research organization/external collaborations to ensure translational supportDiscover and evaluate candidate biomarkersDevelop, validate, and implement quantitative biomarker assays in preclinical models and clinical samplesRoutinely perform LC/MS-based, SIMOA, MSD, and/or ELISA-based quantitative biomarker assays in various biofluid/tissue matricesEvaluate new technologies/platforms to support novel qualitative/quantitative biomarker assay approachesAnalyze large data sets using bioinformatics tools; Interface with bioinformatics/biostatistics experts when neededDocument experiments and studies in electronic lab notebook; produce reports/summaries for project teamsCommunicate findings to collaborators and managerPerform other essential duties as requiredCandidate Qualifications:Ph.D. degree in Analytical Chemistry, Pharmacology, Biochemistry, Cell Biology, Oncology, Neuroscience, or equivalent with at least 0-2 years (AS), 4+ years (S) of relevant experience; a BS/MS degree with at least 7+ years (SRA) or 12+ years (AS) of relevant experience.Prior experience in independently developing, validating, and executing quantitative biomarker assays for preclinical and clinical biomatrices is requiredFamiliarity with a broad spectrum of laboratory techniques, such as cell culture, SIMOA, MSD, ELISA, qPCR, cytokine profiling, LC/MS, ‘omics, flow cytometry, NGS, and human whole blood assaysKnowledge of PK/PD, and IVD development is preferredBe able to interpret results and clearly communicate observations by both written and verbal formatsWillingness to adopt a hands-on approach to deliver in a start-up biotech environment by planning, executing, and troubleshooting experiments independentlyPrior experience collaborating with biologists and possess record of accomplishment in cross functional team settings; strong collaborative and interpersonal skillsPossess strong organizational and time management skillsPrior experience in successfully implementing, utilizing and leveraging outsourcing strategies is also preferredThe expected annual salary range for this position based on the primary location of California is $100,000 – $150,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position is full-time and qualifies for company benefits.Nitrase Therapeutics is an equal opportunity employer.
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